Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

Integrase (IN), the HIV-1 enzyme responsible for the integration of the viral genome into the chromosomes of infected cells, is the target of the recently approved antiviral raltegravir (RAL). Despite this drug's activity against viruses resistant to other antiretrovirals, failures of raltegrav...

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Autors principals: Delelis, Olivier, Thierry, Sylvain, Subra, Frédéric, Simon, Françoise, Malet, Isabelle, Alloui, Chakib, Sayon, Sophie, Calvez, Vincent, Deprez, Eric, Marcelin, Anne-Geneviève, Tchertanov, Luba, Mouscadet, Jean-François
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798554/
https://ncbi.nlm.nih.gov/pubmed/19901095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01075-09
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