Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

Integrase (IN), the HIV-1 enzyme responsible for the integration of the viral genome into the chromosomes of infected cells, is the target of the recently approved antiviral raltegravir (RAL). Despite this drug's activity against viruses resistant to other antiretrovirals, failures of raltegrav...

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Détails bibliographiques
Auteurs principaux: Delelis, Olivier, Thierry, Sylvain, Subra, Frédéric, Simon, Françoise, Malet, Isabelle, Alloui, Chakib, Sayon, Sophie, Calvez, Vincent, Deprez, Eric, Marcelin, Anne-Geneviève, Tchertanov, Luba, Mouscadet, Jean-François
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798554/
https://ncbi.nlm.nih.gov/pubmed/19901095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01075-09
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