Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo

Integrase (IN), the HIV-1 enzyme responsible for the integration of the viral genome into the chromosomes of infected cells, is the target of the recently approved antiviral raltegravir (RAL). Despite this drug's activity against viruses resistant to other antiretrovirals, failures of raltegrav...

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Hlavní autoři: Delelis, Olivier, Thierry, Sylvain, Subra, Frédéric, Simon, Françoise, Malet, Isabelle, Alloui, Chakib, Sayon, Sophie, Calvez, Vincent, Deprez, Eric, Marcelin, Anne-Geneviève, Tchertanov, Luba, Mouscadet, Jean-François
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798554/
https://ncbi.nlm.nih.gov/pubmed/19901095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01075-09
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