Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules. We show that SQLs do not interfere with virus entry. In fact, concentrations...

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Vydáno v:J Virol
Hlavní autoři: Bonnenfant, Sabine, Thomas, Claire Marie, Vita, Claudio, Subra, Frédéric, Deprez, Eric, Zouhiri, Fatima, Desmaële, Didier, d'Angelo, Jean, Mouscadet, Jean François, Leh, Hervé
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2004
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC415813/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15140970/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.11.5728-5736.2004
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