Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

We have previously shown that styrylquinolines (SQLs) are integrase inhibitors in vitro. They compete with the long terminal repeat substrate for integrase. Here, we describe the cellular mode of action of these molecules. We show that SQLs do not interfere with virus entry. In fact, concentrations...

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Detalhes bibliográficos
Main Authors: Bonnenfant, Sabine, Thomas, Claire Marie, Vita, Claudio, Subra, Frédéric, Deprez, Eric, Zouhiri, Fatima, Desmaële, Didier, d'Angelo, Jean, Mouscadet, Jean François, Leh, Hervé
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC415813/
https://ncbi.nlm.nih.gov/pubmed/15140970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.11.5728-5736.2004
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