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Efficient and Specific Internal Cleavage of a Retroviral Palindromic DNA Sequence by Tetrameric HIV-1 Integrase

BACKGROUND: HIV-1 integrase (IN) catalyses the retroviral integration process, removing two nucleotides from each long terminal repeat and inserting the processed viral DNA into the target DNA. It is widely assumed that the strand transfer step has no sequence specificity. However, recently, it has...

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Dettagli Bibliografici
Autori principali: Delelis, Olivier, Parissi, Vincent, Leh, Hervé, Mbemba, Gladys, Petit, Caroline, Sonigo, Pierre, Deprez, Eric, Mouscadet, Jean-François
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905944/
https://ncbi.nlm.nih.gov/pubmed/17622353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000608
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