Two-long terminal repeat (LTR) DNA circles are a substrate for HIV-1 integrase

Integration of the HIV-1 DNA into the host genome is essential for viral replication and is catalyzed by the retroviral integrase. To date, the only substrate described to be involved in this critical reaction is the linear viral DNA produced in reverse transcription. However, during HIV-1 infection...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Richetta, Clémence, Thierry, Sylvain, Thierry, Eloise, Lesbats, Paul, Lapaillerie, Delphine, Munir, Soundasse, Subra, Frédéric, Leh, Hervé, Deprez, Eric, Parissi, Vincent, Delelis, Olivier
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Microbiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6527176/
https://ncbi.nlm.nih.gov/pubmed/30971426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006755
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