Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration

BACKGROUND: Genomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. A consequence is an excess of unintegrated viral DNA genomes, which undergo intramolecular ligation and accumulate as 2-LTR circles. These circularized genomes are als...

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Bibliografiske detaljer
Udgivet i:Retrovirology
Main Authors: Thierry, Sylvain, Munir, Soundasse, Thierry, Eloïse, Subra, Frédéric, Leh, Hervé, Zamborlini, Alessia, Saenz, Dyana, Levy, David N, Lesbats, Paul, Saïb, Ali, Parissi, Vincent, Poeschla, Eric, Deprez, Eric, Delelis, Olivier
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372172/
https://ncbi.nlm.nih.gov/pubmed/25808736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0153-9
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