Integrase inhibitor reversal dynamics indicate unintegrated HIV-1 dna initiate de novo integration

BACKGROUND: Genomic integration, an obligate step in the HIV-1 replication cycle, is blocked by the integrase inhibitor raltegravir. A consequence is an excess of unintegrated viral DNA genomes, which undergo intramolecular ligation and accumulate as 2-LTR circles. These circularized genomes are als...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Retrovirology
Päätekijät: Thierry, Sylvain, Munir, Soundasse, Thierry, Eloïse, Subra, Frédéric, Leh, Hervé, Zamborlini, Alessia, Saenz, Dyana, Levy, David N, Lesbats, Paul, Saïb, Ali, Parissi, Vincent, Poeschla, Eric, Deprez, Eric, Delelis, Olivier
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372172/
https://ncbi.nlm.nih.gov/pubmed/25808736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-015-0153-9
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