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A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles

Retroviral integration is central to viral persistence and pathogenesis, cancer as well as host genome evolution. However, it is unclear why integration appears essential for retrovirus production, especially given the abundance and transcriptional potential of non-integrated viral genomes. The invo...

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Hlavní autoři: Delelis, Olivier, Petit, Caroline, Leh, Herve, Mbemba, Gladys, Mouscadet, Jean-François, Sonigo, Pierre
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180852/
https://ncbi.nlm.nih.gov/pubmed/15904533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-2-31
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