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Probing Resistance Mutations in Retroviral Integrases by Direct Measurement of Dolutegravir Fluorescence
FDA-approved integrase strand transfer inhibitors (raltegravir, elvitegravir and dolutegravir) efficiently inhibit HIV-1 replication. Here, we present fluorescence properties of these inhibitors. Dolutegravir displays an excitation mode particularly dependent on Mg(2+) chelation, allowing to directl...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5656594/ https://ncbi.nlm.nih.gov/pubmed/29070877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14564-w |
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