A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2

par Kuhlmann, Naila, Milnerwood, Austen J.
Publié dans Front Mol Neurosci (2020)

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

par Milnerwood, Austen J, Raymond, Lynn A
Publié 2007

Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons

par Kuhlmann, Naila, Wagner Valladolid, Miriam, Quesada-Ramírez, Lucía, Farrer, Matthew J., Milnerwood, Austen J.
Publié dans Front Cell Neurosci (2021)

Pathophysiology of Huntington’s Disease: Time-Dependent Alterations in Synaptic and Receptor Function

par Raymond, Lynn A., André, Véronique M., Cepeda, Carlos, Gladding, Clare M., Milnerwood, Austen J., Levine, Michael S.
Publié 2011

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out

par MacIsaac, Sarah, Quevedo Melo, Thaiany, Zhang, Yuting, Volta, Mattia, Farrer, Matthew J, Milnerwood, Austen J
Publié dans Brain Commun (2020)

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

par Gladding, Clare M., Sepers, Marja D., Xu, Jian, Zhang, Lily Y.J., Milnerwood, Austen J., Lombroso, Paul J., Raymond, Lynn A.
Publié 2012

Palmitoylation of δ-catenin by DHHC5 Mediates Activity-Induced Synapse Plasticity

par Brigidi, G. Stefano, Sun, Yu, Beccano-Kelly, Dayne, Pitman, Kimberley, Mobasser, Mahsan, Borgland, Stephanie L., Milnerwood, Austen J., Bamji, Shernaz X.
Publié dans Nat Neurosci (2014)

Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice

par Cataldi, Stefano, Follett, Jordan, Fox, Jesse D., Tatarnikov, Igor, Kadgien, Chelsie, Gustavsson, Emil K., Khinda, Jaskaran, Milnerwood, Austen J., Farrer, Matthew J.
Publié dans NPJ Parkinsons Dis (2018)

Memory and synaptic deficits in Hip14/DHHC17 knockout mice

par Milnerwood, Austen J., Parsons, Matthew P., Young, Fiona B., Singaraja, Roshni R., Franciosi, Sonia, Volta, Mattia, Bergeron, Sabrina, Hayden, Michael R., Raymond, Lynn A.
Publié 2013

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

par Kaufman, Alexandra M., Milnerwood, Austen J., Sepers, Marja D., Coquinco, Ainsley, She, Kevin, Wang, Liang, Lee, Hwan, Craig, Ann Marie, Cynader, Max, Raymond, Lynn A.
Publié dans J Neurosci (2012)

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

par Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.
Publié 2014

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

par Volpicelli-Daley, Laura A., Abdelmotilib, Hisham, Liu, Zhiyong, Stoyka, Lindsay, Daher, João Paulo Lima, Milnerwood, Austen J., Unni, Vivek K., Hirst, Warren D., Yue, Zhenyu, Zhao, Hien T., Fraser, Kyle, Kennedy, Richard E., West, Andrew B.
Publié dans J Neurosci (2016)

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

par Volta, Mattia, Beccano-Kelly, Dayne A, Paschall, Sarah A, Cataldi, Stefano, MacIsaac, Sarah E, Kuhlmann, Naila, Kadgien, Chelsie A, Tatarnikov, Igor, Fox, Jesse, Khinda, Jaskaran, Mitchell, Emma, Bergeron, Sabrina, Melrose, Heather, Farrer, Matthew J, Milnerwood, Austen J
Publié dans eLife (2017)

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

par Singaraja, Roshni R., Huang, Kun, Sanders, Shaun S., Milnerwood, Austen J., Hines, Rochelle, Lerch, Jason P., Franciosi, Sonia, Drisdel, Renaldo C., Vaid, Kuljeet, Young, Fiona B., Doty, Crystal, Wan, Junmei, Bissada, Nagat, Henkelman, R. Mark, Green, William N., Davis, Nicholas G., Raymond, Lynn A., Hayden, Michael R.
Publié 2011

DNAJC13 mutations in Parkinson disease

par Vilariño-Güell, Carles, Rajput, Alex, Milnerwood, Austen J., Shah, Brinda, Szu-Tu, Chelsea, Trinh, Joanne, Yu, Irene, Encarnacion, Mary, Munsie, Lise N., Tapia, Lucia, Gustavsson, Emil K., Chou, Patrick, Tatarnikov, Igor, Evans, Daniel M., Pishotta, Frederick T., Volta, Mattia, Beccano-Kelly, Dayne, Thompson, Christina, Lin, Michelle K., Sherman, Holly E., Han, Heather J., Guenther, Bruce L., Wasserman, Wyeth W., Bernard, Virginie, Ross, Colin J., Appel-Cresswell, Silke, Stoessl, A. Jon, Robinson, Christopher A., Dickson, Dennis W., Ross, Owen A., Wszolek, Zbigniew K., Aasly, Jan O., Wu, Ruey-Meei, Hentati, Faycal, Gibson, Rachel A., McPherson, Peter S., Girard, Martine, Rajput, Michele, Rajput, Ali H., Farrer, Matthew J.
Publié 2014

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

par Chartier-Harlin, Marie-Christine, Dachsel, Justus C., Vilariño-Güell, Carles, Lincoln, Sarah J., Leprêtre, Frédéric, Hulihan, Mary M., Kachergus, Jennifer, Milnerwood, Austen J., Tapia, Lucia, Song, Mee-Sook, Le Rhun, Emilie, Mutez, Eugénie, Larvor, Lydie, Duflot, Aurélie, Vanbesien-Mailliot, Christel, Kreisler, Alexandre, Ross, Owen A., Nishioka, Kenya, Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Melrose, Heather L., Behrouz, Bahareh, Keeling, Brett H., Bacon, Justin A., Hentati, Emna, Williams, Lindsey, Yanagiya, Akiko, Sonenberg, Nahum, Lockhart, Paul J., Zubair, Abba C., Uitti, Ryan J., Aasly, Jan O., Krygowska-Wajs, Anna, Opala, Grzegorz, Wszolek, Zbigniew K., Frigerio, Roberta, Maraganore, Demetrius M., Gosal, David, Lynch, Tim, Hutchinson, Michael, Bentivoglio, Anna Rita, Valente, Enza Maria, Nichols, William C., Pankratz, Nathan, Foroud, Tatiana, Gibson, Rachel A., Hentati, Faycal, Dickson, Dennis W., Destée, Alain, Farrer, Matthew J.
Publié 2011