A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2

Por Kuhlmann, Naila, Milnerwood, Austen J.
Publicado no Front Mol Neurosci (2020)

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

Por Milnerwood, Austen J, Raymond, Lynn A
Publicado em 2007

Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons

Por Kuhlmann, Naila, Wagner Valladolid, Miriam, Quesada-Ramírez, Lucía, Farrer, Matthew J., Milnerwood, Austen J.
Publicado no Front Cell Neurosci (2021)

Pathophysiology of Huntington’s Disease: Time-Dependent Alterations in Synaptic and Receptor Function

Por Raymond, Lynn A., André, Véronique M., Cepeda, Carlos, Gladding, Clare M., Milnerwood, Austen J., Levine, Michael S.
Publicado em 2011

Neuron-autonomous susceptibility to induced synuclein aggregation is exacerbated by endogenous Lrrk2 mutations and ameliorated by Lrrk2 genetic knock-out

Por MacIsaac, Sarah, Quevedo Melo, Thaiany, Zhang, Yuting, Volta, Mattia, Farrer, Matthew J, Milnerwood, Austen J
Publicado no Brain Commun (2020)

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

Por Gladding, Clare M., Sepers, Marja D., Xu, Jian, Zhang, Lily Y.J., Milnerwood, Austen J., Lombroso, Paul J., Raymond, Lynn A.
Publicado em 2012

Palmitoylation of δ-catenin by DHHC5 Mediates Activity-Induced Synapse Plasticity

Por Brigidi, G. Stefano, Sun, Yu, Beccano-Kelly, Dayne, Pitman, Kimberley, Mobasser, Mahsan, Borgland, Stephanie L., Milnerwood, Austen J., Bamji, Shernaz X.
Publicado no Nat Neurosci (2014)

Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice

Por Cataldi, Stefano, Follett, Jordan, Fox, Jesse D., Tatarnikov, Igor, Kadgien, Chelsie, Gustavsson, Emil K., Khinda, Jaskaran, Milnerwood, Austen J., Farrer, Matthew J.
Publicado no NPJ Parkinsons Dis (2018)

Memory and synaptic deficits in Hip14/DHHC17 knockout mice

Por Milnerwood, Austen J., Parsons, Matthew P., Young, Fiona B., Singaraja, Roshni R., Franciosi, Sonia, Volta, Mattia, Bergeron, Sabrina, Hayden, Michael R., Raymond, Lynn A.
Publicado em 2013

Opposing Roles of Synaptic and Extrasynaptic NMDA Receptor Signaling in Cocultured Striatal and Cortical Neurons

Por Kaufman, Alexandra M., Milnerwood, Austen J., Sepers, Marja D., Coquinco, Ainsley, She, Kevin, Wang, Liang, Lee, Hwan, Craig, Ann Marie, Cynader, Max, Raymond, Lynn A.
Publicado no J Neurosci (2012)

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Por Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.
Publicado em 2014

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

Por Volpicelli-Daley, Laura A., Abdelmotilib, Hisham, Liu, Zhiyong, Stoyka, Lindsay, Daher, João Paulo Lima, Milnerwood, Austen J., Unni, Vivek K., Hirst, Warren D., Yue, Zhenyu, Zhao, Hien T., Fraser, Kyle, Kennedy, Richard E., West, Andrew B.
Publicado no J Neurosci (2016)

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

Por Volta, Mattia, Beccano-Kelly, Dayne A, Paschall, Sarah A, Cataldi, Stefano, MacIsaac, Sarah E, Kuhlmann, Naila, Kadgien, Chelsie A, Tatarnikov, Igor, Fox, Jesse, Khinda, Jaskaran, Mitchell, Emma, Bergeron, Sabrina, Melrose, Heather, Farrer, Matthew J, Milnerwood, Austen J
Publicado no eLife (2017)

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

Por Singaraja, Roshni R., Huang, Kun, Sanders, Shaun S., Milnerwood, Austen J., Hines, Rochelle, Lerch, Jason P., Franciosi, Sonia, Drisdel, Renaldo C., Vaid, Kuljeet, Young, Fiona B., Doty, Crystal, Wan, Junmei, Bissada, Nagat, Henkelman, R. Mark, Green, William N., Davis, Nicholas G., Raymond, Lynn A., Hayden, Michael R.
Publicado em 2011

DNAJC13 mutations in Parkinson disease

Por Vilariño-Güell, Carles, Rajput, Alex, Milnerwood, Austen J., Shah, Brinda, Szu-Tu, Chelsea, Trinh, Joanne, Yu, Irene, Encarnacion, Mary, Munsie, Lise N., Tapia, Lucia, Gustavsson, Emil K., Chou, Patrick, Tatarnikov, Igor, Evans, Daniel M., Pishotta, Frederick T., Volta, Mattia, Beccano-Kelly, Dayne, Thompson, Christina, Lin, Michelle K., Sherman, Holly E., Han, Heather J., Guenther, Bruce L., Wasserman, Wyeth W., Bernard, Virginie, Ross, Colin J., Appel-Cresswell, Silke, Stoessl, A. Jon, Robinson, Christopher A., Dickson, Dennis W., Ross, Owen A., Wszolek, Zbigniew K., Aasly, Jan O., Wu, Ruey-Meei, Hentati, Faycal, Gibson, Rachel A., McPherson, Peter S., Girard, Martine, Rajput, Michele, Rajput, Ali H., Farrer, Matthew J.
Publicado em 2014

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

Por Chartier-Harlin, Marie-Christine, Dachsel, Justus C., Vilariño-Güell, Carles, Lincoln, Sarah J., Leprêtre, Frédéric, Hulihan, Mary M., Kachergus, Jennifer, Milnerwood, Austen J., Tapia, Lucia, Song, Mee-Sook, Le Rhun, Emilie, Mutez, Eugénie, Larvor, Lydie, Duflot, Aurélie, Vanbesien-Mailliot, Christel, Kreisler, Alexandre, Ross, Owen A., Nishioka, Kenya, Soto-Ortolaza, Alexandra I., Cobb, Stephanie A., Melrose, Heather L., Behrouz, Bahareh, Keeling, Brett H., Bacon, Justin A., Hentati, Emna, Williams, Lindsey, Yanagiya, Akiko, Sonenberg, Nahum, Lockhart, Paul J., Zubair, Abba C., Uitti, Ryan J., Aasly, Jan O., Krygowska-Wajs, Anna, Opala, Grzegorz, Wszolek, Zbigniew K., Frigerio, Roberta, Maraganore, Demetrius M., Gosal, David, Lynch, Tim, Hutchinson, Michael, Bentivoglio, Anna Rita, Valente, Enza Maria, Nichols, William C., Pankratz, Nathan, Foroud, Tatiana, Gibson, Rachel A., Hentati, Faycal, Dickson, Dennis W., Destée, Alain, Farrer, Matthew J.
Publicado em 2011