Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

In Huntington's disease (HD), the mutant huntingtin (mhtt) protein is associated with striatal dysfunction and degeneration. Excitotoxicity and early synaptic defects are attributed, in part, to altered NMDA receptor (NMDAR) trafficking and function. Deleterious extrasynaptic NMDAR localization...

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Autores principales: Gladding, Clare M., Sepers, Marja D., Xu, Jian, Zhang, Lily Y.J., Milnerwood, Austen J., Lombroso, Paul J., Raymond, Lynn A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412376/
https://ncbi.nlm.nih.gov/pubmed/22523092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds154
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