Alterations in Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Expression, Activation and Downstream Signaling in Early and Late Stages of the YAC128 Huntington’s Disease Mouse Model

Striatal neurodegeneration and synaptic dysfunction in Huntington’s disease (HD) are mediated by the mutant huntingtin protein (mHtt). MHtt disrupts calcium homeostasis and facilitates excitotoxicity, in part by altering NMDA receptor (NMDAR) trafficking and function. Presymptomatic (excitotoxin-sen...

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Bibliografiset tiedot
Päätekijät: Gladding, Clare M., Fan, Jing, Zhang, Lily Y. J., Wang, Liang, Xu, Jian, Li, Edward H. Y., Lombroso, Paul J., Raymond, Lynn A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065618/
https://ncbi.nlm.nih.gov/pubmed/24588402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12700
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