Alterations in Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Expression, Activation and Downstream Signaling in Early and Late Stages of the YAC128 Huntington’s Disease Mouse Model

Striatal neurodegeneration and synaptic dysfunction in Huntington’s disease (HD) are mediated by the mutant huntingtin protein (mHtt). MHtt disrupts calcium homeostasis and facilitates excitotoxicity, in part by altering NMDA receptor (NMDAR) trafficking and function. Presymptomatic (excitotoxin-sen...

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Detalhes bibliográficos
Main Authors: Gladding, Clare M., Fan, Jing, Zhang, Lily Y. J., Wang, Liang, Xu, Jian, Li, Edward H. Y., Lombroso, Paul J., Raymond, Lynn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065618/
https://ncbi.nlm.nih.gov/pubmed/24588402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12700
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