Alterations in Striatal-Enriched Protein Tyrosine Phosphatase (STEP) Expression, Activation and Downstream Signaling in Early and Late Stages of the YAC128 Huntington’s Disease Mouse Model

Striatal neurodegeneration and synaptic dysfunction in Huntington’s disease (HD) are mediated by the mutant huntingtin protein (mHtt). MHtt disrupts calcium homeostasis and facilitates excitotoxicity, in part by altering NMDA receptor (NMDAR) trafficking and function. Presymptomatic (excitotoxin-sen...

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Main Authors: Gladding, Clare M., Fan, Jing, Zhang, Lily Y. J., Wang, Liang, Xu, Jian, Li, Edward H. Y., Lombroso, Paul J., Raymond, Lynn A.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065618/
https://ncbi.nlm.nih.gov/pubmed/24588402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12700
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