G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 kinase activity. However, the interaction between α-synuclein, LRRK2, and the formation of α-synuclein inclusions remai...

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Argitaratua izan da:J Neurosci
Egile Nagusiak: Volpicelli-Daley, Laura A., Abdelmotilib, Hisham, Liu, Zhiyong, Stoyka, Lindsay, Daher, João Paulo Lima, Milnerwood, Austen J., Unni, Vivek K., Hirst, Warren D., Yue, Zhenyu, Zhao, Hien T., Fraser, Kyle, Kennedy, Richard E., West, Andrew B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2016
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Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945663/
https://ncbi.nlm.nih.gov/pubmed/27413152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3642-15.2016
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