G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

Pathologic inclusions define α-synucleinopathies that include Parkinson's disease (PD). The most common genetic cause of PD is the G2019S LRRK2 mutation that upregulates LRRK2 kinase activity. However, the interaction between α-synuclein, LRRK2, and the formation of α-synuclein inclusions remai...

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Publicado en:J Neurosci
Main Authors: Volpicelli-Daley, Laura A., Abdelmotilib, Hisham, Liu, Zhiyong, Stoyka, Lindsay, Daher, João Paulo Lima, Milnerwood, Austen J., Unni, Vivek K., Hirst, Warren D., Yue, Zhenyu, Zhao, Hien T., Fraser, Kyle, Kennedy, Richard E., West, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945663/
https://ncbi.nlm.nih.gov/pubmed/27413152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3642-15.2016
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