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Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease. Past studies have provided conflicting evidence for the protective effects of LRRK2 knockdown in models of Parkinson disease as well as other disorders. These discrepancies may be caused by un...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Daher, João P. L., Volpicelli-Daley, Laura A., Blackburn, Jonathan P., Moehle, Mark S., West, Andrew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078806/
https://ncbi.nlm.nih.gov/pubmed/24927544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403215111
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