α-Synuclein Fibril-induced Inclusion Spread in Rats and Mice Correlates with Dopaminergic Neurodegeneration

Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein. The factors contributing to the spread of pathology a...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Abdelmotilib, Hisham, Maltbie, Tyler, Delic, Vedad, Liu, Zhiyong, Hu, Xianzhen, Fraser, Kyle B., Moehle, Mark S., Stoyka, Lindsay, Anabtawi, Nadia, Krendelchtchikova, Valentina, Volpicelli-Daley, Laura A., West, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701756/
https://ncbi.nlm.nih.gov/pubmed/28576704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.05.014
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