Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets

Por McConnell, Jeanette R., McAlpine, Shelli R.
Publicado em 2013

A heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock response

Por McConnell, Jeanette R., Alexander, Leslie A., McAlpine, Shelli R.
Publicado no Bioorg Med Chem Lett (2013)

Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins

Por Ardi, Veronica C., Alexander, Leslie D., Johnson, Victoria, McAlpine, Shelli R.
Publicado em 2011

Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers

Por Kim, Seong Jong, Ramsey, Deborah M., Boyer, Cyrille, Davis, Thomas P., McAlpine, Shelli R.
Publicado em 2013

Histone Deacetylase Inhibitors: Synthesis of Cyclic Tetrapeptides and their Triazole Analogues

Por Singh, Erinprit K., Nazarova, Lidia A., Lapera, Stephanie A., Alexander, Leslie D., McAlpine, Shelli R.
Publicado em 2010

Macrocyclic Inhibitors of Hsp90

Por Johnson, Victoria A., Singh, Erinprit K., Nazarova, Lidia A., Alexander, Leslie D., McAlpine, Shelli R.
Publicado em 2010

Progress towards the synthesis of Urukthapelstatin A and two analogues

Por Pan, Chung-Mao, Lin, Chun-Chieh, Kim, Seong Jong, Sellers, Robert P., McAlpine, Shelli R.
Publicado em 2012

RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles

Por Pietkiewicz, Adrian L., Zhang, Yuqi, Rahimi, Marwa N., Stramandinoli, Michael, Teusner, Matthew, McAlpine, Shelli R.
Publicado no ACS Med Chem Lett (2017)

Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

Por Vasko, Robert C., Rodriguez, Rodrigo A., Cunningham, Christian N., Ardi, Veronica C., Agard, David A., McAlpine, Shelli R.
Publicado em 2010

A structure-activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activity

Por Kim, Seong Jong, Lin, Chun Chieh, Pan, Chung-Mao, Rananaware, Dimple P., Ramsey, Deborah M., McAlpine, Shelli R.
Publicado em 2012

Synthesis and Evaluation of Biotinylated Sansalvamide A Analogs and their Modulation of Hsp90

Por Kunicki, Joseph B., Petersen, Mark N., Alexander, Leslie D., Ardi, Veronica C., McConnell, Jeanette R., McAlpine, Shelli R.
Publicado em 2011

An Hsp90 modulator that exhibits a unique mechanistic profile

Por Ramsey, Deborah M., McConnell, Jeanette R., Alexander, Leslie D., Tanaka, Kaishin W., Vera, Chester M., McAlpine, Shelli R.
Publicado em 2012

A Potential Rhodium Cancer Therapy: Studies of a Cytotoxic Organorhodium (I) Complex that Binds DNA

Por McConnell, Jeanette R., Rananaware, Dimple P, Ramsey, Deborah M., Buys, Kai N., Cole, Marcus L., McAlpine, Shelli R.
Publicado em 2013

Chemically Accessible Hsp90 Inhibitor That Does Not Induce a Heat Shock Response

Por Koay, Yen Chin, McConnell, Jeanette R., Wang, Yao, Kim, Seong Jong, Buckton, Laura K., Mansour, Flora, McAlpine, Shelli R.
Publicado em 2014

Evaluation of Di-Sansalvamide A derivatives: Synthesis, structure-activity relationship, and mechanism of action

Por Alexander, Leslie D., Sellers, Robert P., Davis, Melinda R., Ardi, Veronica C., Johnson, Victoria A., Vasko, Robert C., McAlpine, Shelli R.
Publicado em 2009

Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: A cyclic tetrapeptide scaffold

Por Singh, Erinprit K., Ravula, Suchitra, Pan, Chung-Mao, Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Weerasinghe, Sujith V. W., Pflum, Mary Kay H., McAlpine, Shelli R.
Publicado em 2008

Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds

Por Davis, Melinda R., Singh, Erinprit K., Wahyudi, Hendra, Alexander, Leslie D., Kunicki, Joseph B., Nazarova, Lidia A., Fairweather, Kelly A., Giltrap, Andrew M., Jolliffe, Katrina A., McAlpine, Shelli R.
Publicado em 2012

A comprehensive study of Sansalvamide A derivatives: the structure-activity relationships of 78 derivatives in 2 pancreatic cancer cell lines

Por Pan, Po-Shen, Vasko, Robert C., Lapera, Stephanie A., Johnson, Victoria A., Sellers, Robert P., Lin, Chun-Chieh, Pan, Chung-Mao, Davis, Melinda R., Ardi, Veronica C., McAlpine, Shelli R.
Publicado em 2009

Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity

Por Malle, Elisabeth K., Zammit, Nathan W., Walters, Stacey N., Koay, Yen Chin, Wu, Jianmin, Tan, Bernice M., Villanueva, Jeanette E., Brink, Robert, Loudovaris, Tom, Cantley, James, McAlpine, Shelli R., Hesselson, Daniel, Grey, Shane T.
Publicado no J Exp Med (2015)

Design and synthesis of Hsp90 Inhibitors: exploring the SAR of Sansalvamide A derivatives

Por Sellers, Robert P., Alexander, Leslie D., Johnson, Victoria A., Lin, Chun-Chieh, Savage, Jeremiah, Corral, Ricardo, Moss, Jason, Slugocki, Tim S., Singh, Erinprit K., Davis, Melinda R., Ravula, Suchitra, Spicer, Jamie E., Oelrich, Jenna L., Thornquist, Andrea, Pan, Chung-Mao, McAlpine, Shelli R.
Publicado em 2010