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Synthesis and Evaluation of Biotinylated Sansalvamide A Analogs and their Modulation of Hsp90
Described are the syntheses of 3 Sansalvamide A derivatives that contain biotinylated tags at individual positions around the macrocycle. The tagged derivatives indicated in protein pull-down assays that they bind to Hsp90 at the same binding site (N-middle domain) as the San A-amide peptide. Furthe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155875/ https://ncbi.nlm.nih.gov/pubmed/21764310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.083 |
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