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Design and synthesis of Hsp90 Inhibitors: exploring the SAR of Sansalvamide A derivatives

Utilizing the structure-activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to the interaction of these molecules with the key oncogenic protein Hsp90, we report here the design of 32 new Sansalvamide A derivatives and...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Sellers, Robert P., Alexander, Leslie D., Johnson, Victoria A., Lin, Chun-Chieh, Savage, Jeremiah, Corral, Ricardo, Moss, Jason, Slugocki, Tim S., Singh, Erinprit K., Davis, Melinda R., Ravula, Suchitra, Spicer, Jamie E., Oelrich, Jenna L., Thornquist, Andrea, Pan, Chung-Mao, McAlpine, Shelli R.
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2010
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2933939/ https://ncbi.nlm.nih.gov/pubmed/20708938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.07.042
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Design and synthesis of Hsp90 Inhibitors: exploring the SAR of Sansalvamide A derivatives

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