Design and synthesis of Hsp90 Inhibitors: exploring the SAR of Sansalvamide A derivatives

Utilizing the structure-activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to the interaction of these molecules with the key oncogenic protein Hsp90, we report here the design of 32 new Sansalvamide A derivatives and...

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書誌詳細
主要な著者: Sellers, Robert P., Alexander, Leslie D., Johnson, Victoria A., Lin, Chun-Chieh, Savage, Jeremiah, Corral, Ricardo, Moss, Jason, Slugocki, Tim S., Singh, Erinprit K., Davis, Melinda R., Ravula, Suchitra, Spicer, Jamie E., Oelrich, Jenna L., Thornquist, Andrea, Pan, Chung-Mao, McAlpine, Shelli R.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933939/
https://ncbi.nlm.nih.gov/pubmed/20708938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.07.042
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