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Using NMR to identify binding regions for N and C-terminal Hsp90 inhibitors using Hsp90 domains
We present the first NMR study of the interaction between heat shock protein 90 (Hsp90) and amino (N)-terminal inhibitors 17-AAG, and AUY922, and carboxy (C)-terminal modulators SM253, and LB51. We show that the two ATP mimics, 17-AAG and AUY922, bind deeply within the ATP binding pocket of the N-te...
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| Publicado no: | RSC Med Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8044635/ https://ncbi.nlm.nih.gov/pubmed/33898992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00387e |
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