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Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds

Peptidomimetic-based macrocycles typically have improved pharmacokinetic properties over those observed with peptide analogs. Described are the syntheses of 13 peptidomimetic derivatives that are based on active Sansalvamide A structures, where these analogs incorporate heterocycles (triazoles, oxaz...

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Detalhes bibliográficos
Main Authors: Davis, Melinda R., Singh, Erinprit K., Wahyudi, Hendra, Alexander, Leslie D., Kunicki, Joseph B., Nazarova, Lidia A., Fairweather, Kelly A., Giltrap, Andrew M., Jolliffe, Katrina A., McAlpine, Shelli R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266378/
https://ncbi.nlm.nih.gov/pubmed/22287031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.11.089
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