Structure-activity of Sansalvamide A Derivatives and their Apoptotic Activity in the Pancreatic Cancer Cell Line PL-45

We report the structure-activity relationship (SAR) of forty Sansalvamide A (San A) derivatives against human pancreatic ductal adenicarcinoma cell line PL-45. Our comprehensive evaluation of these compounds utilizes: cytotoxicity based SAR, molecular modeling, and ApoAlert Annexin V apoptosis detec...

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Detalhes bibliográficos
Publicado no:Journal of the Mexican Chemical Society
Main Authors: Rodrigo A. Rodríguez, Po-Shen Pan, Robert C. Vasko, Chung-Mao Pan, William S. Disman, Shelli R. McAlpine
Formato: Artigo
Idioma:Inglês
Publicado em: Sociedad Química de México 2008
Assuntos:
Química
Structure
apoptosis
Sansalvamide A
molecular modeling
activity relationship
Acesso em linha:https://www.redalyc.org/articulo.oa?id=47512078005
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