Histone Deacetylase Inhibitors: Synthesis of Cyclic Tetrapeptides and their Triazole Analogues

Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives are described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrates that incorporation of a triazole unit improves the HDAC inhibitory activity.

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Hlavní autoři: Singh, Erinprit K., Nazarova, Lidia A., Lapera, Stephanie A., Alexander, Leslie D., McAlpine, Shelli R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941989/
https://ncbi.nlm.nih.gov/pubmed/20865132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.06.050
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