Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking

par Margaria, Jean Piero, Ratto, Edoardo, Gozzelino, Luca, Li, Huayi, Hirsch, Emilio
Publié dans Biomolecules (2019)

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors

par Galli, Ubaldina, Ciraolo, Elisa, Massarotti, Alberto, Margaria, Jean Piero, Sorba, Giovanni, Hirsch, Emilio, Tron, Gian Cesare
Publié dans Molecules (2015)

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

par Jenkins, Meredith L., Margaria, Jean Piero, Stariha, Jordan T. B., Hoffmann, Reece M., McPhail, Jacob A., Hamelin, David J., Boulanger, Martin J., Hirsch, Emilio, Burke, John E.
Publié dans Nat Commun (2018)

A Novel Multiplex qRT-PCR Assay to Detect SARS-CoV-2 Infection: High Sensitivity and Increased Testing Capacity

par Petrillo, Sara, Carrà, Giovanna, Bottino, Paolo, Zanotto, Elisa, De Santis, Maria Chiara, Margaria, Jean Piero, Giorgio, Alessandro, Mandili, Giorgia, Martini, Miriam, Cavallo, Rossana, Barberio, Davide, Altruda, Fiorella
Publié dans Microorganisms (2020)

Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation

par Franco, Irene, Margaria, Jean Piero, De Santis, Maria Chiara, Ranghino, Andrea, Monteyne, Daniel, Chiaravalli, Marco, Pema, Monika, Campa, Carlo Cosimo, Ratto, Edoardo, Gulluni, Federico, Perez-Morga, David, Somlo, Stefan, Merlo, Giorgio R., Boletta, Alessandra, Hirsch, Emilio
Publié dans J Am Soc Nephrol (2016)

Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

par Pirali, Tracey, Ciraolo, Elisa, Aprile, Silvio, Massarotti, Alberto, Berndt, Alex, Griglio, Alessia, Serafini, Marta, Mercalli, Valentina, Landoni, Clarissa, Campa, Carlo Cosimo, Margaria, Jean Piero, Silva, Rangel L., Grosa, Giorgio, Sorba, Giovanni, Williams, Roger, Hirsch, Emilio, Tron, Gian Cesare
Publié dans ChemMedChem (2017)

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

par Franco, Irene, Gulluni, Federico, Campa, Carlo C., Costa, Carlotta, Margaria, Jean Piero, Ciraolo, Elisa, Martini, Miriam, Monteyne, Daniel, De Luca, Elisa, Germena, Giulia, Posor, York, Maffucci, Tania, Marengo, Stefano, Haucke, Volker, Falasca, Marco, Perez-Morga, David, Boletta, Alessandra, Merlo, Giorgio R., Hirsch, Emilio
Publié 2014

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation

par Gulluni, Federico, Prever, Lorenzo, Li, Huayi, Krafcikova, Petra, Corrado, Ilaria, Lo, Wen-Ting, Margaria, Jean Piero, Chen, Anlu, De Santis, Maria Chiara, Cnudde, Sophie J., Fogerty, Joseph, Yuan, Alex, Massarotti, Alberto, Sarijalo, Nasrin Torabi, Vadas, Oscar, Williams, Roger L., Thelen, Marcus, Powell, David R., Schüler, Markus, Wiesener, Michael S., Balla, Tamas, Baris, Hagit N., Tiosano, Dov, McDermott, Brian M., Perkins, Brian D., Ghigo, Alessandra, Martini, Miriam, Haucke, Volker, Boura, Evzen, Merlo, Giorgio Roberto, Buchner, David A., Hirsch, Emilio
Publié dans Science (2021)