Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

Activation of the phosphoinositide 3‐kinase (PI3K) pathway is a key signaling event in cancer, inflammation, and other proliferative diseases. PI3K inhibitors are already approved for some specific clinical indications, but their systemic on‐target toxicity limits their larger use. In particular, wh...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Pirali, Tracey, Ciraolo, Elisa, Aprile, Silvio, Massarotti, Alberto, Berndt, Alex, Griglio, Alessia, Serafini, Marta, Mercalli, Valentina, Landoni, Clarissa, Campa, Carlo Cosimo, Margaria, Jean Piero, Silva, Rangel L., Grosa, Giorgio, Sorba, Giovanni, Williams, Roger, Hirsch, Emilio, Tron, Gian Cesare
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697638/
https://ncbi.nlm.nih.gov/pubmed/28857471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700340
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