PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that PI3K-C2α is enriched in the pericentriolar recycling endocytic compartment (PRE)...

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Hlavní autoři: Franco, Irene, Gulluni, Federico, Campa, Carlo C., Costa, Carlotta, Margaria, Jean Piero, Ciraolo, Elisa, Martini, Miriam, Monteyne, Daniel, De Luca, Elisa, Germena, Giulia, Posor, York, Maffucci, Tania, Marengo, Stefano, Haucke, Volker, Falasca, Marco, Perez-Morga, David, Boletta, Alessandra, Merlo, Giorgio R., Hirsch, Emilio
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042153/
https://ncbi.nlm.nih.gov/pubmed/24697898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.01.022
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