Prion neurodegeneration: Starts and stops at the synapse

Por Mallucci, Giovanna R
Publicado em 2009

Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory

Por Halliday, Mark, Mallucci, Giovanna R.
Publicado no Neuropathol Appl Neurobiol (2015)

Therapy for prion diseases: Insights from the use of RNA interference

Por White, Melanie D, Mallucci, Giovanna R
Publicado em 2009

The unfolded protein response: mechanisms and therapy of neurodegeneration

Por Smith, Heather L., Mallucci, Giovanna R.
Publicado no Brain (2016)

Prions: Generation and Spread Versus Neurotoxicity

Por Halliday, Mark, Radford, Helois, Mallucci, Giovanna R.
Publicado em 2014

Fine‐tuning PERK signaling for neuroprotection

Por Halliday, Mark, Hughes, Daniel, Mallucci, Giovanna R.
Publicado no J Neurochem (2017)

miRNAs-19b, -29b-2* and -339-5p Show an Early and Sustained Up-Regulation in Ischemic Models of Stroke

Por Dhiraj, Dalbir K., Chrysanthou, Elvina, Mallucci, Giovanna R., Bushell, Martin
Publicado em 2013

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

Por Radford, Helois, Moreno, Julie A., Verity, Nicholas, Halliday, Mark, Mallucci, Giovanna R.
Publicado no Acta Neuropathol (2015)

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

Por White, Melanie D., Farmer, Michael, Mirabile, Ilaria, Brandner, Sebastian, Collinge, John, Mallucci, Giovanna R.
Publicado em 2008

Nerve injury induces robust allodynia and ectopic discharges in Na(v)1.3 null mutant mice

Por Nassar, Mohammed A, Baker, Mark D, Levato, Alessandra, Ingram, Rachel, Mallucci, Giovanna, McMahon, Stephen B, Wood, John N
Publicado em 2006

Targeting Synaptic Pathology with a Novel Affinity Mass Spectrometry Approach

Por Brinkmalm, Ann, Brinkmalm, Gunnar, Honer, William G., Moreno, Julie A., Jakobsson, Joel, Mallucci, Giovanna R., Zetterberg, Henrik, Blennow, Kaj, Öhrfelt, Annika
Publicado em 2014

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis

Por Knight, John R.P., Bastide, Amandine, Peretti, Diego, Roobol, Anne, Roobol, Jo, Mallucci, Giovanna R., Smales, C. Mark, Willis, Anne E.
Publicado no RNA (2016)

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

Por Peretti, Diego, Bastide, Amandine, Radford, Helois, Verity, Nicholas, Molloy, Colin, Martin, Maria Guerra, Moreno, Julie A., Steinert, Joern R, Smith, Tim, Dinsdale, David, Willis, Anne E., Mallucci, Giovanna R.
Publicado no Nature (2015)

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Por Halliday, Mark, Radford, Helois, Zents, Karlijn A. M., Molloy, Collin, Moreno, Julie A., Verity, Nicholas C., Smith, Ewan, Ortori, Catharine A., Barrett, David A., Bushell, Martin, Mallucci, Giovanna R.
Publicado no Brain (2017)

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease

Por Tufi, Roberta, Gandhi, Sonia, de Castro, Inês P., Lehmann, Susann, Angelova, Plamena R., Dinsdale, David, Deas, Emma, Plun-Favreau, Hélène, Nicotera, Pierluigi, Abramov, Andrey Y., Willis, Anne E., Mallucci, Giovanna R., Loh, Samantha H. Y., Martins, L. Miguel
Publicado em 2014

RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3

Por Bastide, Amandine, Peretti, Diego, Knight, John R.P., Grosso, Stefano, Spriggs, Ruth V., Pichon, Xavier, Sbarrato, Thomas, Roobol, Anne, Roobol, Jo, Vito, Davide, Bushell, Martin, von der Haar, Tobias, Smales, C. Mark, Mallucci, Giovanna R., Willis, Anne E.
Publicado no Curr Biol (2017)

Sustained translational repression by eIF2α–P mediates prion neurodegeneration

Por Moreno, Julie A., Radford, Helois, Peretti, Diego, Steinert, Joern R., Verity, Nicholas, Martin, Maria Guerra, Halliday, Mark, Morgan, Jason, Dinsdale, David, Ortori, Catherine A., Barrett, David A., Tsaytler, Pavel, Bertolotti, Anne, Willis, Anne E., Bushell, Martin, Mallucci, Giovanna R.
Publicado em 2012

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

Por Robinson, Susan W., Bourgognon, Julie-Myrtille, Spiers, Jereme G., Breda, Carlo, Campesan, Susanna, Butcher, Adrian, Mallucci, Giovanna R., Dinsdale, David, Morone, Nobuhiro, Mistry, Raj, Smith, Tim M., Guerra-Martin, Maria, Challiss, R. A. John, Giorgini, Flaviano, Steinert, Joern R.
Publicado no PLoS Biol (2018)

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Por Bradley, Sophie J., Bourgognon, Julie-Myrtille, Sanger, Helen E., Verity, Nicholas, Mogg, Adrian J., White, David J., Butcher, Adrian J., Moreno, Julie A., Molloy, Colin, Macedo-Hatch, Timothy, Edwards, Jennifer M., Wess, Jurgen, Pawlak, Robert, Read, David J., Sexton, Patrick M., Broad, Lisa M., Steinert, Joern R., Mallucci, Giovanna R., Christopoulos, Arthur, Felder, Christian C., Tobin, Andrew B.
Publicado no J Clin Invest (2016)