Sustained translational repression by eIF2α–P mediates prion neurodegeneration

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are associated with the accumulation of misfolded disease-specific proteins. The unfolded protein response (UPR) is a...

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Detalhes bibliográficos
Main Authors: Moreno, Julie A., Radford, Helois, Peretti, Diego, Steinert, Joern R., Verity, Nicholas, Martin, Maria Guerra, Halliday, Mark, Morgan, Jason, Dinsdale, David, Ortori, Catherine A., Barrett, David A., Tsaytler, Pavel, Bertolotti, Anne, Willis, Anne E., Bushell, Martin, Mallucci, Giovanna R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378208/
https://ncbi.nlm.nih.gov/pubmed/22622579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11058
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