Sustained translational repression by eIF2α–P mediates prion neurodegeneration

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are associated with the accumulation of misfolded disease-specific proteins. The unfolded protein response (UPR) is a...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Moreno, Julie A., Radford, Helois, Peretti, Diego, Steinert, Joern R., Verity, Nicholas, Martin, Maria Guerra, Halliday, Mark, Morgan, Jason, Dinsdale, David, Ortori, Catherine A., Barrett, David A., Tsaytler, Pavel, Bertolotti, Anne, Willis, Anne E., Bushell, Martin, Mallucci, Giovanna R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378208/
https://ncbi.nlm.nih.gov/pubmed/22622579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11058
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki