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PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
The PERK-eIF2α branch of the Unfolded Protein Response (UPR) mediates the transient shutdown of translation in response to rising levels of misfolded proteins in the endoplasmic reticulum. PERK and eIF2α activation are increasingly recognised in postmortem analyses of patients with neurodegenerative...
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| Publicado no: | Acta Neuropathol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612323/ https://ncbi.nlm.nih.gov/pubmed/26450683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1487-z |
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