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Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
Prion diseases are fatal neurodegenerative conditions for which there is no effective treatment. Prion propagation involves the conversion of cellular prion protein, PrP(C), to its conformational isomer, PrP(Sc), which accumulates in disease. Here, we show effective therapeutic knockdown of PrP(C) e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474561/ https://ncbi.nlm.nih.gov/pubmed/18632556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802759105 |
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