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Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
Prion diseases are fatal neurodegenerative conditions for which there is no effective treatment. Prion propagation involves the conversion of cellular prion protein, PrP(C), to its conformational isomer, PrP(Sc), which accumulates in disease. Here, we show effective therapeutic knockdown of PrP(C) e...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474561/ https://ncbi.nlm.nih.gov/pubmed/18632556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802759105 |
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