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Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice
Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of PrP(Sc), the infectious and protease-resistant form of the cellular prion protein (PrP(C)). We generated lentivectors expressing PrP(C)-specific short hairpin RNAs (shRNAs) that efficiently silenced expression o...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2006
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679709/ https://ncbi.nlm.nih.gov/pubmed/17143329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29236 |
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