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Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrP(Sc) in prion-infected tissues

BACKGROUND: PrP(Sc), the only known constituent of prions, the infectious agents causing prion diseases, can be detected by real-time quaking-induced conversion (RT-QuIC). However, there is no efficient method to quantify the amount of PrP(Sc) by RT-QuIC. RESULTS: Here we introduce quantitative RT-Q...

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Detalhes bibliográficos
Main Authors: Shi, Song, Mitteregger-Kretzschmar, Gerda, Giese, Armin, Kretzschmar, Hans A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893511/
https://ncbi.nlm.nih.gov/pubmed/24252329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-44
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