Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of PrP(Sc), the infectious and protease-resistant form of the cellular prion protein (PrP(C)). We generated lentivectors expressing PrP(C)-specific short hairpin RNAs (shRNAs) that efficiently silenced expression o...

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Bibliographic Details
Main Authors: Pfeifer, Alexander, Eigenbrod, Sabina, Al-Khadra, Saba, Hofmann, Andreas, Mitteregger, Gerda, Moser, Markus, Bertsch, Uwe, Kretzschmar, Hans
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2006
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679709/
https://ncbi.nlm.nih.gov/pubmed/17143329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29236
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