Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

Prion diseases are fatal neurodegenerative conditions for which there is no effective treatment. Prion propagation involves the conversion of cellular prion protein, PrP(C), to its conformational isomer, PrP(Sc), which accumulates in disease. Here, we show effective therapeutic knockdown of PrP(C) e...

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Bibliographic Details
Main Authors: White, Melanie D., Farmer, Michael, Mirabile, Ilaria, Brandner, Sebastian, Collinge, John, Mallucci, Giovanna R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474561/
https://ncbi.nlm.nih.gov/pubmed/18632556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802759105
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