Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

מאת Corbin, Amie S., Agarwal, Anupriya, Loriaux, Marc, Cortes, Jorge, Deininger, Michael W., Druker, Brian J.
יצא לאור 2010

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

מאת Corbin, Amie S., Agarwal, Anupriya, Loriaux, Marc, Cortes, Jorge, Deininger, Michael W., Druker, Brian J.
יצא לאור 2011

In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia

מאת Glover, Jason M, Loriaux, Marc, Tyner, Jeffrey W, Druker, Brian J, Chang, Bill H
יצא לאור 2012

A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

מאת Johnson, Kara J., Griswold, Ian J., O'Hare, Thomas, Corbin, Amie S., Loriaux, Marc, Deininger, Michael W., Druker, Brian J.
יצא לאור 2009

Crosstalk between ROR1 and the pre-B-Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

מאת Bicocca, Vincent T., Chang, Bill H., Masouleh, Behzad Kharabi, Muschen, Markus, Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
יצא לאור 2012

HitWalker: variant prioritization for personalized functional cancer genomics

מאת Bottomly, Daniel, Wilmot, Beth, Tyner, Jeffrey W., Eide, Christopher A., Loriaux, Marc M., Druker, Brian J., McWeeney, Shannon K.
יצא לאור 2013

Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance

מאת Viola, Shelton, Traer, Elie, Huan, Jianya, Hornick, Noah I., Tyner, Jeffrey W., Agarwal, Anupriya, Loriaux, Marc, Johnstone, Brian, Kurre, Peter
הוצא לאור ב Br J Haematol (2015)

Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth

מאת Dickerson, Erin B, Marley, Kevin, Edris, Wade, Tyner, Jeffrey W, Schalk, Vidya, MacDonald, Valerie, Loriaux, Marc, Druker, Brian J, Helfand, Stuart C
יצא לאור 2013

Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine

מאת Bottomly, Daniel, Ryabinin, Peter A, Tyner, Jeffrey W, Chang, Bill H, Loriaux, Marc M, Druker, Brian J, McWeeney, Shannon K, Wilmot, Beth
יצא לאור 2013

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

מאת Agarwal, Anupriya, Fleischman, Angela G., Petersen, Curtis L., MacKenzie, Ryan, Luty, Samuel, Loriaux, Marc, Druker, Brian J., Woltjer, Randall L., Deininger, Michael W.
יצא לאור 2012

Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma

מאת Siegel, Matthew B., Liu, Selina Qiuying, Davare, Monika A., Spurgeon, Stephen E., Loriaux, Marc M., Druker, Brian J., Scott, Emma C., Tyner, Jeffrey W.
הוצא לאור ב Oncotarget (2015)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

מאת Tyner, Jeffrey W., Bumm, Thomas G., Deininger, Jutta, Wood, Lisa, Aichberger, Karl J., Loriaux, Marc M., Druker, Brian J., Burns, Christopher J., Fantino, Emmanuelle, Deininger, Michael W.
יצא לאור 2010

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

מאת Paiva, Cody, Rowland, Taylor A., Sreekantham, Bhargava, Godbersen, Claire, Best, Scott R., Kaur, Prabhjot, Loriaux, Marc M., Spurgeon, Stephen E.F., Danilova, Olga V., Danilov, Alexey V.
הוצא לאור ב Haematologica (2017)

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

מאת Burke, Russell T, Meadows, Sarah, Loriaux, Marc M, Currie, Kevin S., Mitchell, Scott A., Maciejewski, Patricia, Clarke, Astrid S., Dipaolo, Julie A., Druker, Brian J., Lannutti, Brian J., Spurgeon, Stephen E.
יצא לאור 2014

Absence of SKP2 expression attenuates BCR-ABL–induced myeloproliferative disease

מאת Agarwal, Anupriya, Bumm, Thomas G. P., Corbin, Amie S., O'Hare, Thomas, Loriaux, Marc, VanDyke, Jonathan, Willis, Stephanie G., Deininger, Jutta, Nakayama, Keiichi I., Druker, Brian J., Deininger, Michael W.
יצא לאור 2008

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition

מאת Fleischman, Angela G., Maxson, Julia E., Luty, Samuel B., Agarwal, Anupriya, Royer, Lacey R., Abel, Melissa L., MacManiman, Jason D., Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
יצא לאור 2013

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

מאת Chang, Bill H, Johnson, Kara, LaTocha, Dorian, Rowley, Joelle S J, Bryant, Jade, Burke, Russell, Smith, Rebecca L, Loriaux, Marc, Müschen, Markus, Mullighan, Charles, Druker, Brian J, Tyner, Jeffrey W
הוצא לאור ב J Hematol Oncol (2015)

RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

מאת Tyner, Jeffrey W., Walters, Denise K., Willis, Stephanie G., Luttropp, Mary, Oost, Jason, Loriaux, Marc, Erickson, Heidi, Corbin, Amie S., O'Hare, Thomas, Heinrich, Michael C., Deininger, Michael W., Druker, Brian J.
יצא לאור 2008

RNAi screen for rapid therapeutic target identification in leukemia patients

מאת Tyner, Jeffrey W., Deininger, Michael W., Loriaux, Marc M., Chang, Bill H., Gotlib, Jason R., Willis, Stephanie G., Erickson, Heidi, Kovacsovics, Tibor, O'Hare, Thomas, Heinrich, Michael C., Druker, Brian J.
יצא לאור 2009

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

מאת Tyner, Jeffrey W., Erickson, Heidi, Deininger, Michael W. N., Willis, Stephanie G., Eide, Christopher A., Levine, Ross L., Heinrich, Michael C., Gattermann, Norbert, Gilliland, D. Gary, Druker, Brian J., Loriaux, Marc M.
יצא לאור 2009