Crosstalk between ROR1 and the pre-B-Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Por Bicocca, Vincent T., Chang, Bill H., Masouleh, Behzad Kharabi, Muschen, Markus, Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
Publicado em 2012

HitWalker: variant prioritization for personalized functional cancer genomics

Por Bottomly, Daniel, Wilmot, Beth, Tyner, Jeffrey W., Eide, Christopher A., Loriaux, Marc M., Druker, Brian J., McWeeney, Shannon K.
Publicado em 2013

Comparison of methods to identify aberrant expression patterns in individual patients: augmenting our toolkit for precision medicine

Por Bottomly, Daniel, Ryabinin, Peter A, Tyner, Jeffrey W, Chang, Bill H, Loriaux, Marc M, Druker, Brian J, McWeeney, Shannon K, Wilmot, Beth
Publicado em 2013

Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma

Por Siegel, Matthew B., Liu, Selina Qiuying, Davare, Monika A., Spurgeon, Stephen E., Loriaux, Marc M., Druker, Brian J., Scott, Emma C., Tyner, Jeffrey W.
Publicado no Oncotarget (2015)

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Por Tyner, Jeffrey W., Bumm, Thomas G., Deininger, Jutta, Wood, Lisa, Aichberger, Karl J., Loriaux, Marc M., Druker, Brian J., Burns, Christopher J., Fantino, Emmanuelle, Deininger, Michael W.
Publicado em 2010

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Por Paiva, Cody, Rowland, Taylor A., Sreekantham, Bhargava, Godbersen, Claire, Best, Scott R., Kaur, Prabhjot, Loriaux, Marc M., Spurgeon, Stephen E.F., Danilova, Olga V., Danilov, Alexey V.
Publicado no Haematologica (2017)

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor

Por Burke, Russell T, Meadows, Sarah, Loriaux, Marc M, Currie, Kevin S., Mitchell, Scott A., Maciejewski, Patricia, Clarke, Astrid S., Dipaolo, Julie A., Druker, Brian J., Lannutti, Brian J., Spurgeon, Stephen E.
Publicado em 2014

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition

Por Fleischman, Angela G., Maxson, Julia E., Luty, Samuel B., Agarwal, Anupriya, Royer, Lacey R., Abel, Melissa L., MacManiman, Jason D., Loriaux, Marc M., Druker, Brian J., Tyner, Jeffrey W.
Publicado em 2013

RNAi screen for rapid therapeutic target identification in leukemia patients

Por Tyner, Jeffrey W., Deininger, Michael W., Loriaux, Marc M., Chang, Bill H., Gotlib, Jason R., Willis, Stephanie G., Erickson, Heidi, Kovacsovics, Tibor, O'Hare, Thomas, Heinrich, Michael C., Druker, Brian J.
Publicado em 2009

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients

Por Tyner, Jeffrey W., Erickson, Heidi, Deininger, Michael W. N., Willis, Stephanie G., Eide, Christopher A., Levine, Ross L., Heinrich, Michael C., Gattermann, Norbert, Gilliland, D. Gary, Druker, Brian J., Loriaux, Marc M.
Publicado em 2009

Met receptor sequence variants R970C and T992I lack transforming capacity

Por Tyner, Jeffrey W., Fletcher, Luke B., Wang, Ellen Q., Yang, Wayne F., Rutenberg-Schoenberg, Michael L., Beadling, Carol, Mori, Motomi, Heinrich, Michael C., Deininger, Michael W., Druker, Brian J., Loriaux, Marc M.
Publicado em 2010

Potent Activity of Ponatinib (AP24534) in Models of FLT3-Driven Acute Myeloid Leukemia and Other Hematologic Malignancies

Por Gozgit, Joseph M., Wong, Matthew J., Wardwell, Scott, Tyner, Jeffrey W., Loriaux, Marc M., Mohemmad, Qurish K., Narasimhan, Narayana I., Shakespeare, William C., Wang, Frank, Druker, Brian J., Clackson, Tim, Rivera, Victor M.
Publicado em 2011

The Selective Syk Inhibitor P505-15 (PRT062607) Inhibits B Cell Signaling and Function In Vitro and In Vivo and Augments the Activity of Fludarabine in Chronic Lymphocytic Leukemia

Por Spurgeon, Stephen E., Coffey, Greg, Fletcher, Luke B., Burke, Russell, Tyner, Jeffrey W., Druker, Brian J., Betz, Andreas, DeGuzman, Francis, Pak, Yvonne, Baker, Dale, Pandey, Anjali, Hollenbach, Stanley J., Sinha, Uma, Loriaux, Marc M.
Publicado em 2013

Therapeutically targetable ALK mutations in leukemia

Por Maxson, Julia E., Davare, Monika A., Luty, Samuel B., Eide, Christopher A., Chang, Bill H., Loriaux, Marc M., Tognon, Cristina E., Bottomly, Daniel, Wilmot, Beth, McWeeney, Shannon K., Druker, Brian J., Tyner, Jeffrey W.
Publicado no Cancer Res (2015)

The Colony Stimulating Factor 3 Receptor T640N mutation is oncogenic, sensitive to JAK inhibition, and mimics T618I

Por Maxson, Julia E., Luty, Samuel B., MacManiman, Jason D., Paik, Jason C., Gotlib, Jason, Greenberg, Peter, Bahamadi, Swaleh, Savage, Samantha L., Abel, Melissa L., Eide, Christopher A., Loriaux, Marc M., Stevens, Emily A., Tyner, Jeffrey W.
Publicado no Clin Cancer Res (2015)

An Adaptive Src-PDGFRA-Raf Axis in Rhabdomyosarcoma

Por Abraham, Jinu, Chua, Ying Xuan, Glover, Jason M., Tyner, Jeffrey W., Loriaux, Marc M., Kilcoyne, Aoife, Giles, Francis J., Nelon, Laura D., Carew, Jennifer S., Ouyang, Yongjian, Michalek, Joel E., Pal, Ranadip, Druker, Brian J., Rubin, Brian P., Keller, Charles
Publicado em 2012

CAL-101, a p110δ selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

Por Lannutti, Brian J., Meadows, Sarah A., Herman, Sarah E. M., Kashishian, Adam, Steiner, Bart, Johnson, Amy J., Byrd, John C., Tyner, Jeffrey W., Loriaux, Marc M., Deininger, Mike, Druker, Brian J., Puri, Kamal D., Ulrich, Roger G., Giese, Neill A.
Publicado em 2011

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Por Beer, Philip A., Knapp, David J. H. F., Miller, Paul H., Kannan, Nagarajan, Sloma, Ivan, Heel, Kathy, Babovic, Sonja, Bulaeva, Elizabeth, Rabu, Gabrielle, Terry, Jefferson, Druker, Brian J., Loriaux, Marc M., Loeb, Keith R., Radich, Jerald P., Erber, Wendy N., Eaves, Connie J.
Publicado no Blood (2015)

TSLP Signaling Network Revealed by SILAC-Based Phosphoproteomics

Por Zhong, Jun, Kim, Min-Sik, Chaerkady, Raghothama, Wu, Xinyan, Huang, Tai-Chung, Getnet, Derese, Mitchell, Christopher J., Palapetta, Shyam M., Sharma, Jyoti, O'Meally, Robert N., Cole, Robert N., Yoda, Akinori, Moritz, Albrecht, Loriaux, Marc M., Rush, John, Weinstock, David M., Tyner, Jeffrey W., Pandey, Akhilesh
Publicado em 2012

A gene expression signature of CD34(+) cells to predict major cytogenetic response in chronic-phase chronic myeloid leukemia patients treated with imatinib

Por McWeeney, Shannon K., Pemberton, Lucy C., Loriaux, Marc M., Vartanian, Kristina, Willis, Stephanie G., Yochum, Gregory, Wilmot, Beth, Turpaz, Yaron, Pillai, Raji, Druker, Brian J., Snead, Jennifer L., MacPartlin, Mary, O'Brien, Stephen G., Melo, Junia V., Lange, Thoralf, Harrington, Christina A., Deininger, Michael W. N.
Publicado em 2010