SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia

Although small molecule inhibitors of B-cell receptor-associated kinases have revolutionized therapy in chronic lymphocytic leukemia (CLL), responses are incomplete. Pro-survival signaling emanating from the microenvironment may foster therapeutic resistance of the malignant B cells resident in the...

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Veröffentlicht in:Haematologica
Hauptverfasser: Paiva, Cody, Rowland, Taylor A., Sreekantham, Bhargava, Godbersen, Claire, Best, Scott R., Kaur, Prabhjot, Loriaux, Marc M., Spurgeon, Stephen E.F., Danilova, Olga V., Danilov, Alexey V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664393/
https://ncbi.nlm.nih.gov/pubmed/28838991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.170571
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