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The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NFκB activation and induces apoptosis in chronic lymphocytic leukemia B-cells
BACKGROUND: Stromal-mediated signaling enhances NFκB pathway activity in chronic lymphocytic leukemia B-cells (CLL), leading to cell survival and chemoresistance. Ubiquitination of IκBα may partially account for constitutive activation of NFκB. MLN4924 is an investigational agent that inhibits the N...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3960291/ https://ncbi.nlm.nih.gov/pubmed/24634471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0987 |
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