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A gatekeeper residue for NEDD8 activating enzyme inhibition by MLN4924
Inhibition of NEDD8 activating enzyme (NAE) has emerged as a highly promising approach to treat cancer through the adenosine sulfamate analogue MLN4924. Here we show that selective pressure results in HCT116 colorectal carcinoma cells with decreased MLN4924 sensitivity and identify a single nucleoti...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120840/ https://ncbi.nlm.nih.gov/pubmed/22832224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.02.006 |
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