Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells

The NEDD8-activating enzyme (NAE) initiates neddylation, the cascade of post-translational NEDD8 conjugation onto target proteins. MLN4924, a selective NAE inhibitor, has displayed preclinical anti-tumor activity in vitro and in vivo, and promising clinical activity has been reported in patients wit...

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Main Authors: Xu, G. Wei, Toth, Julia I., da Silva, Sara R., Paiva, Stacey-Lynn, Lukkarila, Julie L., Hurren, Rose, Maclean, Neil, Sukhai, Mahadeo A., Bhattacharjee, Rabindra N., Goard, Carolyn A., Gunning, Patrick T., Dhe-Paganon, Sirano, Petroski, Matthew D., Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972249/
https://ncbi.nlm.nih.gov/pubmed/24691136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093530
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