Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Sequestration in the bone marrow niche may allow leukemic stem cells to evade exposure to drugs. Because the CXCR4/SDF-1 axis is an important mechanism of leukemic stem cell interaction with marrow stroma, we tested whether plerixafor, an antagonist of CXCR4, may dislodge chronic myeloid leukemia (C...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Agarwal, Anupriya, Fleischman, Angela G., Petersen, Curtis L., MacKenzie, Ryan, Luty, Samuel, Loriaux, Marc, Druker, Brian J., Woltjer, Randall L., Deininger, Michael W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2012
विषय:
Myeloid Neoplasia
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460687/
https://ncbi.nlm.nih.gov/pubmed/22889761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-355396
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