Imatinib and Dasatinib Inhibit Hemangiosarcoma and Implicate PDGFR-β and Src in Tumor Growth

Hemangiosarcoma, a natural model of human angiosarcoma, is an aggressive vascular tumor diagnosed commonly in dogs. The documented expression of several receptor tyrosine kinases (RTKs) by these tumors makes them attractive targets for therapeutic intervention using tyrosine kinase inhibitors (TKIs)...

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Main Authors: Dickerson, Erin B, Marley, Kevin, Edris, Wade, Tyner, Jeffrey W, Schalk, Vidya, MacDonald, Valerie, Loriaux, Marc, Druker, Brian J, Helfand, Stuart C
格式: Artigo
語言:Inglês
出版: Neoplasia Press Inc. 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610544/
https://ncbi.nlm.nih.gov/pubmed/23544168
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