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Dasatinib Modulates Invasive and Migratory Properties of Canine Osteosarcoma and has Therapeutic Potential in Affected Dogs

BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant th...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Marley, Kevin, Gullaba, Justine, Seguin, Bernard, Gelberg, Howard B., Helfand, Stuart C.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562978/
https://ncbi.nlm.nih.gov/pubmed/26310368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2015.03.006
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