RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia

Despite vast improvements in our understanding of cancer genetics, a large percentage of cancer cases present without knowledge of the causative genetic events. Tyrosine kinases are frequently implicated in the pathogenesis of numerous types of cancer, but identification and validation of tyrosine k...

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Detalhes bibliográficos
Main Authors: Tyner, Jeffrey W., Walters, Denise K., Willis, Stephanie G., Luttropp, Mary, Oost, Jason, Loriaux, Marc, Erickson, Heidi, Corbin, Amie S., O'Hare, Thomas, Heinrich, Michael C., Deininger, Michael W., Druker, Brian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234058/
https://ncbi.nlm.nih.gov/pubmed/18025156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-097253
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